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Article

The interplay between Siglecs and sialylated pathogens

4 Jul 2014

Abstract excerpt

Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors that limit leukocyte activation, and recent research has...

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PMID: 24996821
DOI: 10.1093/glycob/cwu067

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