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Article

NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus.

The Journal of biological chemistry - 21 Sept 2007

Lewis Amanda L, Cao Hongzhi, Patel Silpa K, Diaz Sandra, Ryan Wesley, Carlin Aaron F, Thon Vireak, Lewis Warren G, Varki Ajit, Chen Xi, Nizet Victor

Abstract excerpt

Group B Streptococcus (GBS) is a common cause of neonatal sepsis and meningitis. A major GBS virulence determinant is its sialic acid (Sia)-capped capsular polysaccharide. Recently, we discovered the presence and genetic basis of capsular Sia O-acetylation in GBS. We now characterize a GBS Sia O-acetylesterase that modulates the degree of GBS surface O-acetylation. The GBS Sia O-acetylesterase operates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to N-Acetylneuraminic Acid

Share to Neisseria meningitidis

Share to Polysaccharides, Bacterial

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Source

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Identifiers

PMID: 17646166
DOI: 10.1074/jbc.M700340200
PMCID: PMC2588433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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