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Article

Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact.

Glycobiology - 1 Nov 2009

Weiman Shannon, Dahesh Samira, Carlin Aaron F, Varki Ajit, Nizet Victor, Lewis Amanda L

Abstract excerpt

Group B Streptococcus (GBS) is an important human pathogen and a model system for studying the roles of bacterial glycosylation in host-microbe interactions. Sialic acid (Sia), expressed prominently in the GBS capsular polysaccharide (CPS), mimics mammalian cell surface Sia and can interact with host Sia-binding proteins to subvert immune clearance mechanisms. Our earlier work has shown that GBS partially...

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Source

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Identifiers

PMID: 19643844
DOI: 10.1093/glycob/cwp111
PMCID: PMC2757575

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Source receipt: pubmed, retrieved 7 Sept 2026.

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