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Article

Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.

PloS one - 1 Jan 2012

Vanoverberghe Karine, Lehen'kyi V'yacheslav, Thébault Stéphanie, Raphaël Maylis, Vanden Abeele Fabien, Slomianny Christian, Mariot Pascal, Prevarskaya Natalia

Abstract excerpt

Neuroendocrine differentiation (NED) is a hallmark of advanced androgen-independent prostate cancer, for which no successful therapy exists. NED tumour cells escape apoptotic cell death by alterations of Ca(2+) homeostasis where the store-operated Ca(2+) entry (SOCE) is known to be a key event. We have previously shown that the downregulation of Orai1 protein representing the major molecular component of...

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Identifiers

PMID: 23049826
DOI: 10.1371/journal.pone.0045615
PMCID: PMC3458093

Genes

STIM1
TRPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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