Article

CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer

2021-09-04

Abstract excerpt

Androgen deprivation therapy (ADT) is the main treatment for advanced prostate cancer (PCa) but resistance results in progression to terminal castrate resistant PCa (CRPC), where there is an unmet therapeutic need. Aberrant intracellular calcium (Ca i 2+ ) is known to promote neoplastic transformation and treatment resistance. There is growing evidence that expression of voltage gated calcium channels (VGCC) is i...

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Literature Corpus work: 6f29fc6d-bd4d-5acf-9687-8560731c2e81
DOI: 10.1101/2021.09.03.458558

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