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Article

Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer

15 Feb 2019

Abstract excerpt

Castration-resistant prostate cancer (CRPC) with neuroendocrine differentiation (NED) is a lethal disease for which effective therapies are urgently needed. The mechanism underlying development of CRPC with NED, however, remains largely uncharacterized. In this study, we explored and characterized the functional role of neurotensin (NTS) in cell line and animal models of CRPC with NED. NTS was acutely induced by...

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PMID: 30770901
DOI: 10.1038/s41388-019-0750-5

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