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Article

Down-regulation of the large-conductance Ca(2+)-activated K+ channel, K(Ca)1.1 in the prostatic stromal cells of benign prostate hyperplasia.

Biological & pharmaceutical bulletin - 1 Jan 2012

Niwa Satomi, Ohya Susumu, Kojima Yoshiyuki, Sasaki Shoichi, Yamamura Hisao, Sakuragi Motomu, Kohri Kenjiro, Imaizumi Yuji

Abstract excerpt

Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel encoded by K(Ca)1.1 plays an important role in the control of smooth muscle tone by modulating membrane potential and intracellular Ca(2+) mobilization. BK(Ca) channel is functionally expressed in prostatic smooth muscle cells, and is activated by α(1)-adrenoceptor agonists. The main objective of this study was to elucidate the pathophysiological...

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Identifiers

PMID: 22687410
DOI: 10.1248/bpb.35.737

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