Article
Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.
Cell death & disease - 16 Sept 2010
Flourakis M, Lehen'kyi V, Beck B, Raphaël M, Vandenberghe M, Abeele F V, Roudbaraki M, Lepage G, Mauroy B, Romanin C, Shuba Y, Skryma R, Prevarskaya N
Abstract excerpt
The molecular nature of calcium (Ca(2+))-dependent mechanisms and the ion channels having a major role in the apoptosis of cancer cells remain a subject of debate. Here, we show that the recently identified Orai1 protein represents the major molecular component of endogenous store-operated Ca(2+) entry (SOCE) in human prostate cancer (PCa) cells, and constitutes the principal source of Ca(2+) influx used by the...
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