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Retroviral Integrase Proteins and HIV-1 DNA Integration

6 Oct 2012

Abstract excerpt

Retroviral integrases catalyze two reactions, 3'-processing of viral DNA ends, followed by integration of the processed ends into chromosomal DNA. X-ray crystal structures of integrase-DNA complexes from prototype foamy virus, a member of the Spumavirus genus of Retroviridae, have revealed the structural basis of integration and how clinically relevant integrase strand transfer inhibitors work. Underscoring the...

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PMID: 23043109
DOI: 10.1074/jbc.r112.397760

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