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Article

Multivalent interactions essential for lentiviral integrase function

3 May 2022

Abstract excerpt

Abstract A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into a host cell genome. Reconstitution of the intasome from the maedi-visna virus (MVV), an ovine lentivirus, revealed a large assembly containing sixteen IN subunits 1 . Herein, we report cryo-EM structures of the lentiviral intasome prior to engagement of target DNA and...

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PMID: 35504909
DOI: 10.1038/s41467-022-29928-8

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