Article

Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6

2026-03-09

Abstract excerpt

The block-and-lock strategy aims to achieve a functional cure for human immunodeficiency virus type 1 (HIV-1) infection by enforcing durable, drug-independent silencing of proviral transcription. Several latency-promoting agents have been described that effectively limit viral reactivation in vitro or in animal models. However, most approaches induce only partial or reversible transcriptional repression and have n...

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Literature Corpus work: 37db42ef-b8c3-5a98-bd17-ce71cfee2c0e
DOI: 10.20944/preprints202603.0670.v1

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