Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

The Journal of biological chemistry - 25 Jun 2010

Gupta Kushol, Diamond Tracy, Hwang Young, Bushman Frederic, Van Duyne Gregory D

Abstract excerpt

Integrase (IN) is the catalytic component of the preintegration complex, a large nucleoprotein assembly critical for the integration of the retroviral genome into a host chromosome. Although partial crystal structures of human immunodeficiency virus IN alone and its complex with the integrase binding domain of the host factor PSIP1/lens epithelium-derived growth factor (LEDGF)/p75 are available, many questions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to HIV Integrase
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Protein Structure, Tertiary

Share to Scattering, Radiation

Share to X-Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 20406807
DOI: 10.1074/jbc.M110.114413
PMCID: PMC2888443

Genes

PSIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.PMID 20406807Read ↗

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.Semantic proximity Read ↗

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human CellsSemantic proximity Read ↗

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75Semantic proximity Read ↗

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.Semantic proximity Read ↗

Architecture and assembly of HIV integrase multimers in the absence of DNA substrates.Semantic proximity Read ↗

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.Semantic proximity Read ↗

Multivalent interactions essential for lentiviral integrase functionSemantic proximity Read ↗

Multivalent interactions essential for lentiviral integrase functionSemantic proximity Read ↗

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug DiscoverySemantic proximity Read ↗

Retroviral Integrase Proteins and HIV-1 DNA IntegrationSemantic proximity Read ↗

Structural basis for functional tetramerization of lentiviral integrase.Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.