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Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration

3 Feb 2007

Abstract excerpt

Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of LEDGF on the assembly and activity of HIV-1 synaptic complexes, which, upon association with a target, mediate concerted integration of viral DNA substrates in vitro. We found that while augmenting single-ended viral DNA integration into...

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PMID: 17267486
DOI: 10.1128/jvi.02322-06

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Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted IntegrationPMID 17267486Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitroSemantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 IntegraseSemantic proximity Read ↗

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.Semantic proximity Read ↗

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human CellsSemantic proximity Read ↗

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75Semantic proximity Read ↗

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75Semantic proximity Read ↗

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.Semantic proximity Read ↗

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug DiscoverySemantic proximity Read ↗

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