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Article

Structure-based modeling of the functional HIV-1 intasome and its inhibition

23 Aug 2010

Abstract excerpt

The intasome is the basic recombination unit of retroviral integration, comprising the integrase protein and the ends of the viral DNA made by reverse transcription. Clinical inhibitors preferentially target the DNA-bound form of integrase as compared with the free protein, highlighting the critical requirement for detailed understanding of HIV-1 intasome structure and function. Although previous biochemical...

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PMID: 20733078
DOI: 10.1073/pnas.1002346107

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