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Article

Multivalent interactions essential for lentiviral integrase function

2022-01-27

Abstract excerpt

A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into a host cell genome. Reconstitution of the intasome from the maedi-visna virus (MVV), an ovine lentivirus, revealed a large assembly containing sixteen IN subunits (1). Herein, we report cryo-EM structures of the lentiviral intasome prior to engagement of target DNA and following stran...

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Identifiers and source

Literature Corpus work
98437b22-75d9-5b49-89bd-63d874074379
DOI
10.1101/2022.01.26.477893
Open publication

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Multivalent interactions essential for lentiviral integrase functionDOI 10.1101/2022.01.26.477893
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