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Article

Functional and structural characterization of the integrase from the prototype foamy virus

26 Nov 2008

Abstract excerpt

Establishment of the stable provirus is an essential step in retroviral replication, orchestrated by integrase (IN), a virus-derived enzyme. Until now, available structural information was limited to the INs of human immunodeficiency virus type 1 (HIV-1), avian sarcoma virus (ASV) and their close orthologs from the Lentivirus and Alpharetrovirus genera. Here, we characterized the in vitro activity of the...

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PMID: 19036793
DOI: 10.1093/nar/gkn938

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