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Article

Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor.

PloS one - 1 Jan 2013

Liang Xin, Xu Huijuan, Li Caiyue, Yin Shikui, Xu Tingting, Liu Jinsong, Li Zhiyuan

Abstract excerpt

The transition from the closed to open state greatly alters the intra- and inter-subunit interactions of the P2X receptor (P2XR). The interactions that occur in the transmembrane domain of the P2X2R remain unclear. We used substituted cysteine mutagenesis disulfide mapping to identify pairs of re...

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Identifiers

PMID: 23936459
DOI: 10.1371/journal.pone.0070629
PMCID: PMC3735612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23936459-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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