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Article

Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking.

Purinergic signalling - 1 Jun 2012

Jindrichova Marie, Kuzyk Pavlo, Li Shuo, Stojilkovic Stanko S, Zemkova Hana

Abstract excerpt

The P2X7 receptor (P2X7R) is a member of the ATP-gated ion channel family that exhibits distinct electrophysiological and pharmacological properties. This includes low sensitivity to ATP, lack of desensitization, a sustained current growth during prolonged receptor stimulation accompanied with development of permeability to large organic cations, and the coupling of receptor activation to cell blebbing and death....

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Identifiers

PMID: 22286664
DOI: 10.1007/s11302-012-9291-x
PMCID: PMC3350585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking.PMID 22286664Read ↗

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Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface.Semantic proximity Read ↗

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Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity.Semantic proximity Read ↗

Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms.Semantic proximity Read ↗

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