Article
Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.
Channels (Austin, Tex.) - 1 Jan 2000
Jiang Ruotian, Taly Antoine, Lemoine Damien, Martz Adeline, Specht Alexandre, Grutter Thomas
Abstract excerpt
The molecular mechanism underlying channel opening in response to agonist binding remains a challenging issue in neuroscience. In this regard, many efforts have been recently undertaken in ATP-gated P2X receptors. Among those efforts, we have provided evidence in the P2X2 receptor that tightening of ATP sites upon agonist binding induces opening of the ion channel. Here we extend our analysis to show that the...
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