Article
Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine Leiomyomata.
American journal of human genetics - 5 Oct 2012
Eggert Stacey L, Huyck Karen L, Somasundaram Priya, Kavalla Raghava, Stewart Elizabeth A, Lu Ake T, Painter Jodie N, Montgomery Grant W, Medland Sarah E, Nyholt Dale R, Treloar Susan A, Zondervan Krina T, Heath Andrew C, Madden Pamela A F, Rose Lynda, Buring Julie E, Ridker Paul M, Chasman Daniel I, Martin Nicholas G, Cantor Rita M, Morton Cynthia C
Abstract excerpt
Uterine leiomyomata (UL), the most prevalent pelvic tumors in women of reproductive age, pose a major public health problem given their high frequency, associated morbidities, and most common indication for hysterectomies. A genetic component to UL predisposition is supported by analyses of ethnic predisposition, twin studies, and familial aggregation. A genome-wide SNP linkage panel was genotyped and analyzed in...
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