Integrative analysis of uterine leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, gene targets, and cell types

Abstract excerpt

<title>Abstract</title> <p>Uterine fibroids (UF), also called leiomyomas, are observed in nearly 70% of women of reproductive age. These tumors disrupt normal uterine function and cause significant physical and psychological health problems. Although heritable genetics is a significant risk factor, specific genetic variations and gene targets causally associated with UL are poorly understood. We performed a meta-...

Topics

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• Endometriosis Research and Treatment
• Epigenomics
• Gene Expression Profiling
• Genome-Wide Association Study
• Leiomyoma
• Polymorphism, Single Nucleotide
• Risk Factors
• Uterine Myomas and Treatments

Identifiers and source

Literature Corpus work

49d99785-8d5d-50b1-a67a-41e8fe596f29

DOI

10.21203/rs.3.rs-2548537/v1