Article
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
Nature communications - 24 Oct 2019
Gallagher C S, Mäkinen N, Harris H R, Rahmioglu N, Uimari O, Cook J P, Shigesi N, Ferreira T, Velez-Edwards D R, Edwards T L, Mortlock S, Ruhioglu Z, Day F, Becker C M, Karhunen V, Martikainen H, Järvelin M-R, Cantor R M, Ridker P M, Terry K L, Buring J E, Gordon S D, Medland S E, Montgomery G W, Nyholt D R, Hinds D A, Tung J Y, Perry J R B, Lind P A, Painter J N, Martin N G, Morris A P, Chasman D I, Missmer S A, Zondervan K T, Morton C C
Abstract excerpt
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10-8) loci, in addition to confirming 21 previously reported loci,...
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