Article
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
Nature genetics - 1 May 2011
Cha Pei-Chieng, Takahashi Atsushi, Hosono Naoya, Low Siew-Kee, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke
Abstract excerpt
Uterine fibroids are a common benign tumor of the female genital tract. We conducted a genome-wide association study in which 457,044 SNPs were analyzed in 1,607 individuals with clinically diagnosed uterine fibroids and 1,428 female controls. SNPs showing suggestive associations (P < 5 × 10(-5)) were further genotyped in 3,466 additional cases and 3,245 female controls. Three loci on chromosomes 10q24.33,...
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