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Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

18 Sept 2018

Abstract excerpt

Uterine leiomyomas (ULs) are benign tumors that are a major burden to women’s health. A genome-wide association study on 15,453 UL cases and 392,628 controls was performed, followed by replication of the genomic risk in six cohorts. Effects of the risk alleles were evaluated in view of molecular and clinical characteristics. 22 loci displayed a genome-wide significant association. The likely predisposition genes...

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Share to Endometriosis Research and Treatment
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PMID: 30226466
DOI: 10.7554/elife.37110

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