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Article

Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits

3 Sept 2018

Abstract excerpt

Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with the disease. Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30194396
DOI: 10.1038/s41467-018-05428-6

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