Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.

doi:10.1038/s41467-025-57483-5

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Article

Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.

Nature communications - 6 Mar 2025

Kim Jeewoo, Williams Ariel, Noh Hannah, Jasper Elizabeth A, Jones Sarah H, Jaworski James A, Shuey Megan M, Ruiz-Narváez Edward A, Wise Lauren A, Palmer Julie R, Connolly John, Keaton Jacob M, Denny Joshua C, Khan Atlas, Abbass Mohammad A, Rasmussen-Torvik Laura J, Kottyan Leah C, Madhivanan Purnima, Krupp Karl, Wei Wei-Qi, Edwards Todd L, Velez Edwards Digna R, Hellwege Jacklyn N

Abstract excerpt

Uterine leiomyomata or fibroids are highly heritable, common, and benign tumors of the uterus with poorly understood etiology. Previous GWAS have reported 72 associated genes but included limited numbers of non-European individuals. Here, we identify 11 novel genes associated with fibroids across multi-ancestry and ancestry-stratified GWAS analyses. We replicate a known fibroid GWAS gene in African ancestry...

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Identifiers

PMID: 40050615
DOI: 10.1038/s41467-025-57483-5
PMCID: PMC11885530

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