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Article

Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.

American journal of human genetics - 7 Jul 2022

Wu Xueyao, Xiao Chenghan, Han Zhitong, Zhang Li, Zhao Xunying, Hao Yu, Xiao Jinyu, Gallagher C Scott, Kraft Peter, Morton Cynthia Casson, Li Jiayuan, Jiang Xia

Abstract excerpt

Little is known regarding the shared genetic architecture or causality underlying the phenotypic association observed for uterine leiomyoma (UL) and breast cancer (BC). Leveraging summary statistics from the hitherto largest genome-wide association study (GWAS) conducted in each trait, we investigated the genetic overlap and causal associations of UL with BC overall, as well as with its subtypes defined by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35803233
DOI: 10.1016/j.ajhg.2022.05.015
PMCID: PMC9300879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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