Article
Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases.
BMC medical genetics - 5 Oct 2012
Huhn Stefanie, Bevier Melanie, Rudolph Anja, Pardini Barbara, Naccarati Alessio, Hein Rebecca, Hoffmeister Michael, Vodickova Ludmila, Novotny Jan, Brenner Hermann, Chang-Claude Jenny, Hemminki Kari, Vodicka Pavel, Försti Asta
Abstract excerpt
BACKGROUND: The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases. METHODS: In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech...
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