Article
Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins.
BMC cancer - 5 Aug 2011
Abulí Anna, Fernández-Rozadilla Ceres, Alonso-Espinaco Virginia, Muñoz Jenifer, Gonzalo Victoria, Bessa Xavier, González Dolors, Clofent Joan, Cubiella Joaquin, Morillas Juan D, Rigau Joaquim, Latorre Mercedes, Fernández-Bañares Fernando, Peña Elena, Riestra Sabino, Payá Artemio, Jover Rodrigo, Xicola Rosa M, Llor Xavier, Carvajal-Carmona Luis, Villanueva Cristina M, Moreno Victor, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic...
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