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Associations between blood glucose and early- and late-onset colorectal cancer: evidence from two prospective cohorts and Mendelian randomization analyses

22 Jun 2024

Abstract excerpt

The incidence of early-onset colorectal cancer (EOCRC), which exhibits differential clinical, pathological, and molecular features compared to late-onset CRC (LOCRC), is rising globally. The potential differential effects of blood glucose on EOCRC compared to LOCRC have not been investigated. This study analyzed 374,568 participants from UK Biobank cohort and 172,809 participants from Kailuan cohort. The linear...

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PMID: 39281721
DOI: 10.1016/j.jncc.2024.04.006

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