Article
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.
The Journal of clinical investigation - 1 May 2011
Grachtchouk Marina, Pero Joanna, Yang Steven H, Ermilov Alexandre N, Michael L Evan, Wang Aiqin, Wilbert Dawn, Patel Rajiv M, Ferris Jennifer, Diener James, Allen Mary, Lim Seokchun, Syu Li-Jyun, Verhaegen Monique, Dlugosz Andrzej A
Abstract excerpt
Uncontrolled Hedgehog (Hh) signaling leads to the development of basal cell carcinoma (BCC), the most common human cancer, but the cell of origin for BCC is unclear. While Hh pathway dysregulation is common to essentially all BCCs, there exist multiple histological subtypes, including superficial and nodular variants, raising the possibility that morphologically distinct BCCs may arise from different cellular...
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