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Article

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients.

Human genetics - 1 Feb 1990

Fukuchi K, Tanaka K, Kumahara Y, Marumo K, Pride M B, Martin G M, Monnat R J

Abstract excerpt

The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal...

Topics

Adult
Cells, Cultured
Drug Resistance
Female
Humans
Lymphocytes
Male
Middle Aged
Mutation
Thioguanine
Werner Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2303247
DOI: 10.1007/BF00200569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2303247-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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