Article
Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys).
Environmental and molecular mutagenesis - 1 Jan 1991
Zimmer D M, Aaron C S, O'Neill J P, Albertini R J
Abstract excerpt
We have investigated the use of cynomolgus monkeys (Macaca fascicularis) as a model of somatic cell mutagenesis in non-human primates. Using techniques described by Albertini (Mutation Research 150:411-422, 1985) for similar studies in humans, the frequency of TG-resistant T-lymphocytes in the peripheral blood was determined in animals that were either untreated or treated with ethylnitrosourea. The frequency of...
Topics
- Animals
- Cell Division
- Cell Line
- Clone Cells
- Drug Resistance
- Ethylnitrosourea
- Female
- Macaca fascicularis
- Male
- Models, Genetic
- Mutagenesis
- Phenotype