Article
Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome.
Mechanisms of ageing and development - 1 Aug 2001
Rosner K, Winter D B, Skovgaard G L, Oshima J, Gearhart P J, Bohr V A
Abstract excerpt
Werner syndrome (WS) is a human premature aging syndrome, which is associated with high frequencies of neoplasia and genetic instability. We have examined the occurrence of microsatellite instability, which may result from defective mismatch repair, in lymphoblastoid cell lines derived from nine WS patients. Instability was measured at the D2S123 locus by gel analysis of PCR products. Three WS cell lines had...
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