Article
Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus.
The Journal of experimental medicine - 1 Jan 1992
Gmelig-Meyling F, Dawisha S, Steinberg A D
Abstract excerpt
The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC...
Topics
- Adult
- Arthritis, Rheumatoid
- Cells, Cultured
- Female
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lupus Erythematosus, Systemic
- Male
- Mutation
- Reference Values
- T-Lymphocytes
- Thioguanine