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Article

Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay.

BMC cancer - 3 Oct 2012

Yoshimi Kazuto, Hashimoto Takao, Niwa Yusuke, Hata Kazuya, Serikawa Tadao, Tanaka Takuji, Kuramoto Takashi

Abstract excerpt

BACKGROUND: Chemotherapeutic bioassay for colorectal cancer (CRC) with a rat model bearing chemically-induced CRCs plays an important role in the development of new anti-tumor drugs and regimens. Although several protocols to induce CRCs have been developed, the incidence and number of CRCs are not much enough for the efficient bioassay. Recently, we established the very efficient system to induce CRCs with a...

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Identifiers

PMID: 23031214
DOI: 10.1186/1471-2407-12-448
PMCID: PMC3517449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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