Article
Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 May 2015
Kochi Takahiro, Shimizu Masahito, Shirakami Yohei, Yoshimi Kazuto, Kuramoto Takashi, Tanaka Takuji, Moriwaki Hisataka
Abstract excerpt
Establishment of an efficient rat model for colitis-associated colon carcinogenesis is critical for evaluation of the potency of cancer-preventive agents on carcinogenesis. In the present study, we examined whether the Kyoto Apc Delta (KAD) rat, a novel adenomatous polyposis coli mutant rat strai...
Topics
- Adenomatous Polyposis Coli
- Animals
- Chemoprevention
- Colitis
- Colonic Neoplasms
- Disease Models, Animal
- Male
- Mutation
- Oxidative Stress
- Rats