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Article

Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 May 2015

Kochi Takahiro, Shimizu Masahito, Shirakami Yohei, Yoshimi Kazuto, Kuramoto Takashi, Tanaka Takuji, Moriwaki Hisataka

Abstract excerpt

Establishment of an efficient rat model for colitis-associated colon carcinogenesis is critical for evaluation of the potency of cancer-preventive agents on carcinogenesis. In the present study, we examined whether the Kyoto Apc Delta (KAD) rat, a novel adenomatous polyposis coli mutant rat strain, is useful for detection of potential chemopreventive agents when this rat is used for azoxymethane (AOM) plus...

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PMID: 25222193
DOI: 10.1097/CEJ.0000000000000063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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