Article
High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.
Mutation research - 31 May 2008
Bellocq Delphine, Molina Jérôme, Rathahao Estelle, Canlet Cécile, Taché Sylviane, Martin Pascal G P, Pierre Fabrice, Paris Alain
Abstract excerpt
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a prominent heterocyclic aromatic amine (HAA) found in meat and fish cooked at moderate to high temperature. It is considered as a potent dietary factor promoting colon carcinogenesis. However, the role of intestinal cells in PhIP bioactivation has not been fully explained, particularly when cells are pre-malignant. Loss of function of the adenomatous...
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