Article
Rare frequency of activation of the Ki-ras gene in rat colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis.
Molecular carcinogenesis - 1 Jan 1993
Kakiuchi H, Ushijima T, Ochiai M, Imai K, Ito N, Yachi A, Sugimura T, Nagao M
Abstract excerpt
Heterocyclic amines present in cooked foods are known to produce colon tumors in F344 rats at a high incidence, indicating the possibility of involvement of ras gene activation in colon carcinogenesis in rats as in humans. We examined mutations at codons 12, 13, and 61 of the Ki-ras, Ha-ras, and N-ras genes by polymerase chain reaction--direct sequencing in seven colon tumors in F344 rats induced by...
Topics
- Adenocarcinoma
- Amines
- Animals
- Base Sequence
- Carcinogens
- Codon
- Colonic Neoplasms
- Exons
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Heterocyclic Compounds