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Article

Enhanced colitis‐associated colon carcinogenesis in a novel <i>Apc</i> mutant rat

17 Jul 2009

Abstract excerpt

To establish an efficient rat model for colitis-associated colorectal cancer, azoxymethane and dextran sodium sulfate (AOM/DSS)-induced colon carcinogenesis was applied to a novel adenomatous polyposis coli (Apc) mutant, the Kyoto Apc Delta (KAD) rat. The KAD rat was derived from ethylnitrosourea mutagenesis and harbors a nonsense mutation in the Apc gene (S2523X). The truncated APC of the KAD rat was deduced to...

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PMID: 19694754
DOI: 10.1111/j.1349-7006.2009.01287.x

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