Article
Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet.
Carcinogenesis - 1 Jan 2002
Ubagai Tsuneyuki, Ochiai Masako, Kawamori Toshihiko, Imai Hiroshi, Sugimura Takashi, Nagao Minako, Nakagama Hitoshi
Abstract excerpt
In the present study we have established novel intermittent protocols featuring a high fat (HF) diet for efficient induction of large intestinal tumors with a relatively small amount of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). In protocol 1, F344 male rats were first fed a diet con...
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- Cytoskeletal Proteins
- DNA Mutational Analysis
- Dietary Fats
- Drug Synergism
- Imidazoles
- Intestinal Neoplasms
- Intestine, Large
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational