Article
Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet.
Carcinogenesis - 1 Jan 2002
Ubagai Tsuneyuki, Ochiai Masako, Kawamori Toshihiko, Imai Hiroshi, Sugimura Takashi, Nagao Minako, Nakagama Hitoshi
Abstract excerpt
In the present study we have established novel intermittent protocols featuring a high fat (HF) diet for efficient induction of large intestinal tumors with a relatively small amount of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). In protocol 1, F344 male rats were first fed a diet containing 400 p.p.m. PhIP for 2 weeks, followed by continuous administration of a HF diet without PhIP for 108 weeks. In...
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