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Article

The utility of Apc-mutant rats in modeling human colon cancer

1 Jan 2014

Abstract excerpt

Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for investigating the etiology of cancer. Now, recent advances in the manipulation of the rat genome, combined with a growing recognition of the physiological differences between mice and rats, have reignited interest in the rat as a model of human cancer. Two recently developed rat models, the polyposis in the rat colon...

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PMID: 25288683
DOI: 10.1242/dmm.016980

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