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Article

Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model.

International journal of cancer - 15 Oct 2007

Kohno Hiroyuki, Totsuka Yukari, Yasui Yumiko, Suzuki Rikako, Sugie Shigeyuki, Wakabayashi Keiji, Tanaka Takuji

Abstract excerpt

A novel heterocyclic amine, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman, APNH), which is formed from nonmutagenic 9H-pyrido[3,4-b]indole (norharman) and aniline, is mutagenic to bacteria and mammalian cells and potently carcinogenic in rats. APNH is detected in human urine samples, suggesting that humans are continuously exposed to APNH. In the present study, (32)P-postlabelin analysis...

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Identifiers

PMID: 17557291
DOI: 10.1002/ijc.22864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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