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Article

Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2012

Grenz Almut, Kim Jae-Hwan, Bauerle Jessica D, Tak Eunyoung, Eltzschig Holger K, Clambey Eric T

Abstract excerpt

Renal ischemia is among the leading causes of acute kidney injury (AKI). Previous studies have shown that extracellular adenosine is a prominent tissue-protective cue elicited during ischemia, including signaling events through the adenosine receptor 2b (Adora2b). To investigate the functional role of Adora2b signaling in cytokine-mediated inflammatory pathways, we screened wild-type and Adora2b-deficient mice...

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Identifiers

PMID: 23028059
DOI: 10.4049/jimmunol.1201651
PMCID: PMC3651815

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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