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Article

Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease.

Blood - 10 May 2012

Tsukamoto Hiroki, Chernogorova Petya, Ayata Korcan, Gerlach Ulrike V, Rughani Ankur, Ritchey Jerry W, Ganesan Jayanthi, Follo Marie, Zeiser Robert, Thompson Linda F, Idzko Marco

Abstract excerpt

Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A2A receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5'-nucleotidase in GVHD. In...

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Identifiers

PMID: 22262774
DOI: 10.1182/blood-2011-09-375899
PMCID: PMC3362368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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