New insights into adenosine‐receptor‐mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency

Abstract excerpt

There is growing interest in manipulating adenosine (Ado) signal transduction to control inflammation and autoimmunity. This concept probably originated with the discovery of severe combined immunodeficiency disease (SCID) in infants with inherited deficiency of adenosine deaminase (ADA). However, the basis for immunosuppression by Ado has not been well defined, and effects of 2'-deoxyadenosine (dAdo), which does...

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