Article
Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
Purinergic signalling - 1 Dec 2015
Nayak Shraddha, Khan Md Abdul H, Wan Tina C, Pei Hong, Linden Joel, Dwinell Melinda R, Geurts Aron M, Imig John D, Auchampach John A
Abstract excerpt
The A(2B) adenosine receptor (AR) has emerged as a unique member of the AR family with contrasting roles during acute and chronic disease states. We utilized zinc-finger nuclease technology to create A(2B)AR gene (Adora2b)-disrupted rats on the Dahl salt-sensitive (SS) genetic background. This strategy yielded a rat strain (SS-Adora2b mutant rats) with a 162-base pair in-frame deletion of Adora2b that included...
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