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Article

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.

Pain - 1 Nov 2017

Coddou Claudio, Sandoval Rodrigo, Castro Patricio, Lazcano Pablo, Hevia Maria José, Rokic Milos, Hall Bradford, Terse Anita, Gonzalez-Billault Christian, Kulkarni Ashok B, Stojilkovic Stanko S, Utreras Elias

Abstract excerpt

The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), which is absent in the splice variant P2X2bR. We therefore investigated the effects of Cdk5 and its neuronal activator, p35, on P2X2aR function. We found an...

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Identifiers

PMID: 28809765
DOI: 10.1097/j.pain.0000000000001021
PMCID: PMC5640492

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