Article
Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.
The Journal of clinical endocrinology and metabolism - 1 Nov 2009
Shih Pei-An Betty, Wang Lei, Chiron Stephane, Wen Gen, Nievergelt Caroline, Mahata Manjula, Khandrika Srikrishna, Rao Fangwen, Fung Maple M, Mahata Sushil K, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
RATIONALE: Obesity is a heritable trait that contributes to hypertension and subsequent cardiorenal disease risk; thus, the investigation of genetic variation that predisposes individuals to obesity is an important goal. Circulating peptide YY (PYY) is known for its appetite and energy expenditure-regulating properties; linkage and association studies have suggested that PYY genetic variation contributes to...
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