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Article

Clonal heterogeneity in patients with cytogenetically normal acute myeloid leukemia with NPM1 mutations.

Leukemia & lymphoma - 1 May 2013

Dvorakova Dana, Racil Zdenek, Borsky Marek, Robesova Blanka, Jeziskova Ivana, Razga Filip, Lengerova Martina, Mayer Jiri

Abstract excerpt

The nucleophosmin 1 (NPM1) gene is one of the most commonly mutated genes in acute myeloid leukemia (AML), occurring in approximately 60% of adult cytogenetically normal AML (CN-AML). To date, these mutations have only been detected in cells of the myeloid lineage, whereas the potential clonal involvement of the lymphoid lineage is controversial. In our study, NPM1 mutations were analyzed using the highly...

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Source

Identifiers

PMID: 23020761
DOI: 10.3109/10428194.2012.734618

Genes

NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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